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Chylomicron Remnants Chylomicrons Apolipoprotein B-48 Lipoproteins, VLDL Receptors, LDL Lipoproteins Vitamin A Triglycerides Lymph Apolipoproteins E Liver Low Density Lipoprotein Receptor-Related Protein-1 Fetuins Apolipoproteins Corn Oil Cholesterol Emulsions Lipase Apolipoproteins B Cholesterol Esters Gold Colloid Lipoprotein Lipase Receptors, Lipoprotein Lactoferrin alpha … ical receptor for chylomicron remnants [13]. B. Apo B-48 specific. The role of the LDL receptor in clearance of LDL is well established. Previous. Chylomicron remnants are enriched with endogenous TG fatty acids, compared with their parent chylomicrons, which consist primarily of exogenous TG fatty acids. Chylomicron Remnant: When the triglyceride reserve consumes (distributed), it converts APOC2 back to HDL (which APOE retains), leaving chylomicrons remnants of only 20-50 nm. [Google Scholar] Hui DY, Innerarity TL, Milne RW, Marcel YL, Mahley RW. D. Apo E specific. Very low-density lipoprotein, or VLDL: Produced primarily by the liver, with smaller amounts contributed by the intestine. In previous studies, chylomicron remnants or chylomicron remnant‐like particles (CRLPs) have been shown to induce extensive lipid accumulation in a variety of macrophage types, including the murine macrophage cell line J774 [], mouse peritoneal macrophages [], primary human monocyte‐derived macrophages [[3, 4]] and macrophages derived from the human monocyte cell line THP‐1 [[4, 5, 19, 20]]. Next . Let’s compare Chylomicrons with other terms. Information and translations of chylomicron remnants in the most comprehensive dictionary definitions resource on the web. Keywords: chylomicron remnants; dietary fat; LDL recep- What does chylomicron remnants mean? fats; fatty acid metabolism; Share It On Facebook Twitter Email. 1982 Jan; 23 (1):42–52. Diabetes is now a pandemic disease. The VLDL receptor has been described as a new member of the LDL receptor supergene family that specifically binds VLDL in vitro via apolipoprotein E and lipoprotein lipase. The binding of chylomicron remnants was competitively inhibited in the presence of unlabeled remnants and to a lesser extent by unlabeled low-density lipoproteins. Less clear the signifi- cance of the LDL receptor in clearance chylo- micron remnants. Although both the LDL receptor and the LRP have been implicated in the uptake of chylomicron remnants, it has been difficult to determine which, if either, plays the dominant role in this process. This suggested the receptors were distinct. Both apolipoprotein E and lipoprotein lipase are constituents of chylomicron remnants, another triglyceride-rich lipoprotein which has been proposed as a physiological ligand for the VLDL receptor. 2 years ago | 08/07/2018 14:10:21 | gknowledge. Evidence that chylomicron remnants and 6-VLDL are transported by the same receptor pathway in J774 murine macrophage-derived cells Jeff L. Ellsworth, Allen D. Cooper, and Fredric B. Kraemer' Because enterocytes have the apolipoprotein B-100/E receptor, this study was directed at determining whether the cells can take up and metabolize chylomicron remnants and, if so, whether this was receptor mediated. There are two types of receptors located in the hepatocyte membrane. In addition, while in the space of Disse chylomicron remnants can accumulate additional apoE that is secreted free into the space. This article must therefore be hereby marked "advertise- The absence of any excess remnant accumulation in FHH subjects with varying 'impairment' of LDL receptor-mediated degradation of apo E-containing lipoproteins, permits the conclusion that chylomicron remnants are initially cleared from the plasma by apo E-recognizing receptors which are genetically distinct from LDL receptors. "Chylomicron Remnants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Uptake . Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. The present studies of chylomicron metabolism were conducted in rabbits, since this species has been used extensively in lipoprotein studies. Lipoprotein-receptor related protein (LRP) requires apoE to facilitates the binding of the sequestered remnants to this receptor. Chylomicron remnants require four receptors for binding compared with one receptor per LDL particle [16], suggesting that with LDL receptor-deï¬ cient states, chylomicron remnant clearance may be more signiï¬ cantly compromised than LDL. Definition of chylomicron remnants in the Definitions.net dictionary. Chylomicron: A lipoprotein rich in triglyceride and common in the blood during fat digestion and assimilation. Chylomicron remnants are the post-hydrolytic product of intestinally derived chylo- microns, which are responsible for the transport of dietary lipid [2]. Both type 1 and type 2 diabetes increase the risk of atherosclerotic cardiovascular disease (CVD). chylomicron remnants might provide a useful means of detecting subtle changes in LDL receptor expression. 38 2173-2192. Impaired clearance of chylomicron remnants correlates with increased vascular disease risk in FH. This latter process allows the remnant to be taken up via the chylomicron remnant receptor. chylomicron remnants is influenced both by the fatty acid composition of the particles, and by longer-term adaptive changes in liver tissue, and suggest that the former effects are mediated mainly by the LDL receptor, while the latter may involve both the LDL receptor and the LRP. due, at least in part, to a loss of receptors which can recognize chylomicron remnants. The concentration of chylomicron remnants used for J. Lipid &S. 1997. Fats and Fatty Acid Metabolism. The loss of regulation of cholesterol synthesis by die- tary cholesterol (1) has been well documented in trans- plantable hepatomas (2), in primary hepatomas from several species including man (3,4) and in premalignant liver (5, 6). The liver is the primary organ responsible for the clearance of pro-atherogeniclipoproteins, which include intermediate-density and low-density lipoproteins (IDL and LDL, respectively) and chylomicron remnants. In rabbits, the VLDL receptor has been found predomi-nantly in heart, skeletal muscle, and adipose tissue, but not in the liver [14]. These data demonstrate that in the perfused livers of normal mice at physiological concentrations, remnants are effi-ciently internalized by receptor-mediated endocytosis. Chylomicron remnants bound to rabbit alveolar macrophages with high-affinity (Kd = 3.3 ± 0.71 μg of protein/mL). Therefore, it was suggested that the VLDL receptor may play a role in the uptake of chylomicron remnants in non-hepatic tissues [13]. Meaning of chylomicron remnants. THE low-density-lipoprotein (LDL) receptor is a cell-surface pro-tein that plays an important part in the metabolism of cholesterol by mediating the uptake of LDL from plasma into cells1. receptor is able to bind chylomicron remnants that are formed during the two-step pathway for chylomicron catabolism (1, 7). 1 Answer +1 vote . Supplementary key words chylomicron remnants chylomicron LDL receptor LDL receptor-related protein hepatic lipase heparan sulfate proteoglycan Consideration of lipoprotein metabolism has often been divided into endogenous and exogenous path- ways. Several putative hepatic APOB48 and APOE are important for the identification of chylomicron remnants in the liver due to endocytosis and degradation. Chylomicron remnants were degraded by alveolar macrophages from Watanabe heritable hyperlipidemic (WHHL) rabbits, which are devoid of LDL receptor activity. Moreover, it is impractical to use proper amounts of the tracer, because its tracee, chylomicron remnants, is virtually absent in the plasma of fasted mice (1, 34). remnants moved from the cell surface to the perinu-clear regions over this period (data not shown). J Lipid Res. The two substances did not compete with each other for removal by the isolated perfused rat liver. The metabolism of VLDL is very similar to that of chylomicrons, the major difference being that VLDL are assembled in hepatocytes to transport triglyceride containing fatty acids newly synthesized from excess glucose, or retrieved from the chylomicron remnants, to adipose tissue and muscle. Science 264:1471–1474 CAS VLDL contains relatively large amounts of triglycerides compared to protein. A. Apo A specific . chylomicron remnants is mediated at the surfaces ofparen- chymal liver cells by apolipoprotein B, E (LDL) receptors coded for by a single allelic pair of genes on chromosome 19 Cooper, A. D. Hepatic uptake of chylomicron remnants. During glyceryl trioleate absorption in the rat, mucosal triacylglycerol (TG) fatty acids have been shown to consist of only 71% exogenous oleate. C. Apo C specific . Chylomicron remnants appear in the plasma only after fat ingestion, and never reach a steady state. Chylomicron remnants can then be taken up by hepatocytes via interaction with the LDL receptor which requires apoE. Moreover, a large number of people with prediabetes are at risk for developing frank diabetes worldwide. Even with statin treatment to lower LDL cholesterol, patients with diabetes have a high residual CVD risk. The publication costs of this article were defrayed in part by page charge payment. Receptors for chylomicron remnants are (A) Apo A specific (B) Apo B-48 specific (C) Apo C specific (D) Apo E specific . When the lipoprotein remnants contact them they become bound and sequester (confined) against the hepatic cell membrane. Willnow TE, Sheng Z, Ishibashi S, Herz J (1994) Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Characterization of chylomicron remnant binding to rat liver membranes. The converse also was true. Receptors for chylomicron remnants are? Moreover, colchicine and monensin which are endocytotic and lysozomal inhibitors, respectively, did not have any effect on the degradation of chylomicron remnants by macrophages from normal rabbits. Unlabeled chylomicron remnants did not reduce the binding of 125 I-asiaglycoprotein to plasma membranes, but did compete for 125 I-chylomicron remanant binding. Yl, Mahley RW by hepatocytes via interaction with the LDL receptor expression impaired clearance of chylomicron are. Via the chylomicron remnant binding to rat liver space of Disse chylomicron remnants appear in the only... Were defrayed in part by page charge payment costs of this article were defrayed in part by page charge.! 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